Directions of Reasearch
Extend and refine our maps of epigenetic gene silencing.
Construct comprehensive map of monoallelic expression in the human genome. Expand our initial observations to more individuals and to a larger set of tissue types to shed light on the variability of this epigenetic mechanism.
Expand the analysis of allele-specific expression to the mouse genome to elucidate the evolution of monoallelic expression and provide basis for generating mutant mouse models.
Study chromatin mechanisms underlying the differential allele activity.